rOv-ASP-1, a recombinant secreted protein of the helminth onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens
Identifieur interne : 004D28 ( Main/Exploration ); précédent : 004D27; suivant : 004D29rOv-ASP-1, a recombinant secreted protein of the helminth onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens
Auteurs : Angus J. Macdonald [États-Unis] ; LONG CAO [États-Unis] ; YUXIAN HE [États-Unis] ; QIAN ZHAO [États-Unis] ; SHIBO JIANG [États-Unis] ; Sara Lustigman [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2005.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (pharmacologie), Animaux, Antigènes d'helminthe (administration et posologie), Antigènes d'helminthe (génétique), Antigènes d'helminthe (immunologie), Antigènes d'helminthe (pharmacologie), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Ovalbumine (), Ovalbumine (immunologie), Protéines d'helminthes (pharmacologie), Protéines recombinantes (immunologie), Protéines recombinantes (pharmacologie), Souris, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (immunologie), Virus du SRAS (), Virus du SRAS (immunologie), Vésicules de sécrétion (métabolisme).
- MESH :
- administration et posologie : Antigènes d'helminthe, Vaccins synthétiques.
- génétique : Antigènes d'helminthe.
- immunologie : Antigènes d'helminthe, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Ovalbumine, Protéines recombinantes, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Vaccins synthétiques, Virus du SRAS.
- métabolisme : Vésicules de sécrétion.
- pharmacologie : Adjuvants immunologiques, Antigènes d'helminthe, Protéines d'helminthes, Protéines recombinantes.
- Pascal (Inist)
- Animaux, Helmintha, Onchocerca volvulus, Ovalbumine, Souris, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus HIV1, Protéine recombinante, Sécrétion, Adjuvant immunologique, Anticorps, Ovalbumine, Polypeptide, Peptide, Antigène, Syndrome respiratoire aigu sévère, Lymphocyte T, Lymphocyte Th1, Lymphocyte Th2, Virus du SRAS.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (pharmacology), Animals, Antibody, Antigen, Antigens, Helminth (administration & dosage), Antigens, Helminth (genetics), Antigens, Helminth (immunology), Antigens, Helminth (pharmacology), HIV-1 (drug effects), HIV-1 (immunology), HIV-1 virus, Helminth Proteins (pharmacology), Helmintha, Immunological adjuvant, Mice, Onchocerca volvulus, Ovalbumin, Ovalbumin (chemistry), Ovalbumin (immunology), Peptides, Polypeptide, Recombinant Proteins (immunology), Recombinant Proteins (pharmacology), Recombinant protein, SARS Virus (drug effects), SARS Virus (immunology), Secretion, Secretory Vesicles (metabolism), Severe acute respiratory syndrome, T-Lymphocyte, Th1 Cells (immunology), Th1 lymphocyte, Th2 Cells (immunology), Th2 lymphocyte, Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (immunology).
- MESH :
- chemical , administration & dosage : Antigens, Helminth, Vaccines, Synthetic.
- chemical , chemistry : Ovalbumin.
- chemical , genetics : Antigens, Helminth.
- chemical , immunology : Antigens, Helminth, Ovalbumin, Recombinant Proteins, Vaccines, Synthetic.
- chemical , pharmacology : Adjuvants, Immunologic, Antigens, Helminth, Helminth Proteins, Recombinant Proteins.
- drug effects : HIV-1, SARS Virus.
- immunology : HIV-1, SARS Virus, Th1 Cells, Th2 Cells.
- metabolism : Secretory Vesicles.
- Animals, Mice.
Abstract
We studied the adjuvanticity of recombinant Onchocerca volvulus activation associated protein-1 (rOv-ASP-1) for ovalbumin (OVA) in mice. After a single immunization and one boost, rOv-ASP-1 exceeded the efficacy of alum or MPL+TDM adjuvants in terms of end-point total IgG or IgGI and IgG2a anti-OVA titres. Using the helminth-derived adjuvant, IgG isotype responses to OVA were of a mixed Thl/Th2 profile and spleen cell cytokines exclusively Th1-type. The potent adjuvanticity of rOv-ASP-1 was confirmed in mice vaccinated with a 37-mer peptide from the S protein ofSARS-CoV and an HIV-1 gp120-CD4 chimeric polypeptide antigen. Unusually for a helminth product, the rOr-ASP-1 adjuvant augmented not only Th2 but also Th 1 responses, the latter property being of potential utility in stimulating anti-viral immune responses.
Affiliations:
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Le document en format XML
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Kimball Research Institute, The New York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Long Cao" sort="Long Cao" uniqKey="Long Cao" last="Long Cao">LONG CAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, The New York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yuxian He" sort="Yuxian He" uniqKey="Yuxian He" last="Yuxian He">YUXIAN HE</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Viral Immunology, Lindsley F. 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Macdonald</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, The New York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Long Cao" sort="Long Cao" uniqKey="Long Cao" last="Long Cao">LONG CAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, The New York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yuxian He" sort="Yuxian He" uniqKey="Yuxian He" last="Yuxian He">YUXIAN HE</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, The Neat York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Qian Zhao" sort="Qian Zhao" uniqKey="Qian Zhao" last="Qian Zhao">QIAN ZHAO</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, The Neat York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shibo Jiang" sort="Shibo Jiang" uniqKey="Shibo Jiang" last="Shibo Jiang">SHIBO JIANG</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, The Neat York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lustigman, Sara" sort="Lustigman, Sara" uniqKey="Lustigman S" first="Sara" last="Lustigman">Sara Lustigman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, The New York Blood Center, 310 East 67th Street</s1><s2>New York, NY 10021</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (pharmacology)</term><term>Animals</term><term>Antibody</term><term>Antigen</term><term>Antigens, Helminth (administration & dosage)</term><term>Antigens, Helminth (genetics)</term><term>Antigens, Helminth (immunology)</term><term>Antigens, Helminth (pharmacology)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (immunology)</term><term>HIV-1 virus</term><term>Helminth Proteins (pharmacology)</term><term>Helmintha</term><term>Immunological adjuvant</term><term>Mice</term><term>Onchocerca volvulus</term><term>Ovalbumin</term><term>Ovalbumin (chemistry)</term><term>Ovalbumin (immunology)</term><term>Peptides</term><term>Polypeptide</term><term>Recombinant Proteins (immunology)</term><term>Recombinant Proteins (pharmacology)</term><term>Recombinant protein</term><term>SARS Virus (drug effects)</term><term>SARS Virus (immunology)</term><term>Secretion</term><term>Secretory Vesicles (metabolism)</term><term>Severe acute respiratory syndrome</term><term>T-Lymphocyte</term><term>Th1 Cells (immunology)</term><term>Th1 lymphocyte</term><term>Th2 Cells (immunology)</term><term>Th2 lymphocyte</term><term>Vaccines, Synthetic (administration & dosage)</term><term>Vaccines, Synthetic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (pharmacologie)</term><term>Animaux</term><term>Antigènes d'helminthe (administration et posologie)</term><term>Antigènes d'helminthe (génétique)</term><term>Antigènes d'helminthe (immunologie)</term><term>Antigènes d'helminthe (pharmacologie)</term><term>Lymphocytes auxiliaires Th1 (immunologie)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Ovalbumine ()</term><term>Ovalbumine (immunologie)</term><term>Protéines d'helminthes (pharmacologie)</term><term>Protéines recombinantes (immunologie)</term><term>Protéines recombinantes (pharmacologie)</term><term>Souris</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term><term>Vaccins synthétiques (administration et posologie)</term><term>Vaccins synthétiques (immunologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (immunologie)</term><term>Vésicules de sécrétion (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antigens, Helminth</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Ovalbumin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Ovalbumin</term><term>Recombinant Proteins</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Antigens, Helminth</term><term>Helminth Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term><term>Ovalbumine</term><term>Protéines recombinantes</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Vaccins synthétiques</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV-1</term><term>SARS Virus</term><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Secretory Vesicles</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Vésicules de sécrétion</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Antigènes d'helminthe</term><term>Protéines d'helminthes</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Helmintha</term><term>Onchocerca volvulus</term><term>Ovalbumine</term><term>Souris</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Virus HIV1</term><term>Protéine recombinante</term><term>Sécrétion</term><term>Adjuvant immunologique</term><term>Anticorps</term><term>Ovalbumine</term><term>Polypeptide</term><term>Peptide</term><term>Antigène</term><term>Syndrome respiratoire aigu sévère</term><term>Lymphocyte T</term><term>Lymphocyte Th1</term><term>Lymphocyte Th2</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the adjuvanticity of recombinant Onchocerca volvulus activation associated protein-1 (rOv-ASP-1) for ovalbumin (OVA) in mice. After a single immunization and one boost, rOv-ASP-1 exceeded the efficacy of alum or MPL+TDM adjuvants in terms of end-point total IgG or IgGI and IgG2a anti-OVA titres. Using the helminth-derived adjuvant, IgG isotype responses to OVA were of a mixed Thl/Th2 profile and spleen cell cytokines exclusively Th1-type. The potent adjuvanticity of rOv-ASP-1 was confirmed in mice vaccinated with a 37-mer peptide from the S protein ofSARS-CoV and an HIV-1 gp120-CD4 chimeric polypeptide antigen. Unusually for a helminth product, the rOr-ASP-1 adjuvant augmented not only Th2 but also Th 1 responses, the latter property being of potential utility in stimulating anti-viral immune responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Macdonald, Angus J" sort="Macdonald, Angus J" uniqKey="Macdonald A" first="Angus J." last="Macdonald">Angus J. Macdonald</name></region><name sortKey="Long Cao" sort="Long Cao" uniqKey="Long Cao" last="Long Cao">LONG CAO</name><name sortKey="Lustigman, Sara" sort="Lustigman, Sara" uniqKey="Lustigman S" first="Sara" last="Lustigman">Sara Lustigman</name><name sortKey="Qian Zhao" sort="Qian Zhao" uniqKey="Qian Zhao" last="Qian Zhao">QIAN ZHAO</name><name sortKey="Shibo Jiang" sort="Shibo Jiang" uniqKey="Shibo Jiang" last="Shibo Jiang">SHIBO JIANG</name><name sortKey="Yuxian He" sort="Yuxian He" uniqKey="Yuxian He" last="Yuxian He">YUXIAN HE</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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